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Instituto De Oncología Intervencionista  en

Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia (AML) initially manifests itself in the bone marrow, but can spread rapidly through the blood.

ACUTE MYELOID LEUKEMIA is a type of cancer that usually originates in the stem cells that produce granulocytes (neutrophils, eosinophils or basophils).
It manifests initially in the bone marrow, but in most cases, it spreads rapidly through the blood. In AML, the bone marrow produces many abnormal cancer cells, also called blasts or myeloblasts because they resemble healthy immature blasts. Instead of becoming healthy mature blood cells, cancer cells divide quickly and uncontrollably.
Over time, these myeloblasts fill the bone marrow, prevent the production of healthy cells and then accumulate in the bloodstream. They can also move to the lymph nodes, the brain, the skin, the liver, the kidneys, the ovaries (in girls), the testicles (in boys) and other organs. Occasionally, AML cells form a solid mass or tumor called chloroma.

AML is the second most common form of leukemia in children, after Acute Lymphoblastic Leukemia.
AML in childhood is more frequent during the first two years of life and adolescence. In addition, children who have Down syndrome have an increased risk of developing AML during the first 4 years of life. Children with other bone marrow disorders are also at risk of developing it.

Most of the signs and symptoms of AML are the result of poor production of healthy blood cells by the bone marrow and the accumulation of AML cancer cells:

*Shaking chills.
* Bone and joint pain.
* Swollen lymph nodes.
* Hemorrhages and frequent bruising.
* Appearance or complexion pale or unhealthy.

For the Institute of Interventional Oncology (IDOI Mexico), it is important to remind you that the early signs and symptoms of AML may be very similar to those of influenza or other frequent childhood diseases.
If you are concerned about any changes in your child, seek advice with your doctor.